가토의 두개 결손부에서의 실크 단백질과 platelet-rich fibrin (PRF)의 골형성 효과
The bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) in the calvaria defect of rabbit
송지영, 권해용, 권광준, 박영욱, 김성곤,
소속 상세정보
송지영 ( Song Ji-Young ) - 강릉원주대학교 치과대학 구강악안면외과학교실
권해용 ( Kweon Hae-Yong ) - 농촌진흥청
권광준 ( Kwon Kwang-Jun ) - 강릉원주대학교 치과대학 구강악안면외과학교실
박영욱 ( Park Young-Wook ) - 강릉원주대학교 치과대학 구강악안면외과학교실
김성곤 ( Kim Seong-Gon ) - 강릉원주대학교 치과대학 구강악안면외과학교실
KMID : 0355620100360040250
Abstract
Introduction: This study evaluated the bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) of a bone defect in rabbits. Materials and
Methods: Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter: 8.0 mm). The silk fibroin mixed with PRF was grafted into the right parietal bone (experimental group). The left side (control group) was grafted only PRF. The animals were sacrificed at 4 weeks and 8 weeks. A micro-computerized tomography (μCT) of each specimen was taken. Subsequently, the specimens were decalcified and stained for histological analysis.
Results: The average value of plane film analysis was higher in the experimental group than in the control group at 4 weeks and 8weeks after surgery. However, the difference was not statistically significant.(P>0.05) The tissue mineral density (TMD) in the experimental group at 4 weeks after surgery was significantly higher than the control group.(P<0.05)
Conclusion: Silk fibroin can be used as a scaffold of PRF for rabbit calvarial defect repair.
키워드
Platelet-rich fibrin (PRF); Silk fibroin; Bone regeneration
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